The effect of pre-operative conventional and hyperfractionated radiotherapy schedules on wound healing and tensile strength in rats: an experimental study

. We examined the effects of pre-operative conventional andhyperfractionated radiotherapy schedules on wound healing and tensile strength in90 female Wistar rats weighing between 182 and 240 g. The animals wererandomized into three groups (n ¼ 30 each). Group I was sham-irradiated. GroupII (conventional) received 20 daily fractions of 200 cGy, to a total dose of4000 cGy. Group III (hyperfractionated) received 40 fractions of 120 cGy, twicedaily, to a total dose of 4800 cGy. Four weeks after radiotherapy, incision andprimary repair with simple suturing was performed on one side of the neck.Twenty-one days after wounding, all the rats were sacrificed. Non-parametricKruskal–Wallis and Mann–Whitney U-tests were used for the statistical analysisof wound tensile strength. The chi-squared test was used for the statistical analysisof the histopathologic findings. The hyperfractionated group had a significantlylower tensile strength than that of the control group (P ¼ 0.03, z ¼ 2.18).According to the histopathologic findings, fibrosis was increased significantly inthe hyperfractionated group as compared to the other groups (P ¼ 0.038,w2 ¼ 6.52). Hyperfractionated radiotherapy significantly reduced the wound tensilestrength in the early evaluation period as compared to the control group.


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